Enantiomeric Cyclic Peptides with Different Caco‐2 Permeability Suggest Carrier‐Mediated Transport

Recently, oral absorption of cyclic hexapeptides was improved by N‐methylation of their backbone amides. However, the number and position of N‐methylations or of solvent exposed NHs did not correlate to intestinal permeability, measured in a Caco‐2 model. In this study, we investigate enantiomeric pairs of three polar and two lipophilic peptides to demonstrate the participation of carrier‐mediated transporters. As expected, all the enantiomeric peptides exhibited identical lipophilicity (logD_7.4) and passive transcellular permeability determined by the parallel artificial membrane permeability assay (PAMPA). However, the enantiomeric polar peptides exhibited different Caco‐2 permeability (P_app) in both directions a–b and b–a. The same trend was observed for one of the lipophilic peptide, whereas the second lipophilic enantiomer pair showed identical Caco‐2 permeability (within the errors). These findings provide the first evidence for the involvement of carrier‐mediated transport for peptides, especially for those of polar nature.     

Point availability of Gaver’s duplex system supervised by a safety device unit

We analyse the point availability of Gaver’s parallel system supervised by a safety device. For safety reasons, no unit is allowed to operate without supervision. The entire system is attended by two heterogeneous repairmen. Our methodology is based on the theory of sectionally holomorphic functions combined with the notion of dual transforms. As an application we consider Coxian repair time distributions.     

Order acceptance and scheduling with machine availability constraints

We consider an order acceptance and scheduling model with machine availability constraints. The manufacturer (machine) is assumed to be available to process orders only within a number of discontinuous time intervals. To capture the real-life behavior of a typical manufacturer who has restrictions of time availability to process orders, our model allows the manufacturer to reject or outsource some of the orders. When an order is rejected or outsourced, an order-dependent cost of penalty will occur. The objective is to minimize the makespan of all accepted orders plus the total penalty of all rejected/outsourced orders. We study the approximability of the model and some of its important special cases.     

三线性滞回系统的稳态响应

提出了一种三线性滞回阻尼模型。用Krylov-Bogoliubov缓变系灵敏法研究了正弦型激励下单自由度三线性滞回系统的稳态响应。当本文的三线性模型退化为双线性模型时。本文结果与Caughey的结果是一致的。研究结果还发现。这种系统的稳态解总是稳定的，没有振幅的跳跃现象发生。但在激振力力幅达到一定值时能够发生无界响应。此外还发现，稳态振动达到峰值振幅时滞回面积（即最大滞回面积）对峰值振幅的比值和激振力力幅成正比。这个结论与双非线性滞回系统的相应结论是一致的。     

Dynamics of a Flexible Slider-Crank Mechanism Driven by a Non-Ideal Source of Energy

The dynamic response of a slider crank mechanism with a flexible connecting rod driven by an electric DC motor is examined. After formulating the governing nonlinear boundary value problem, it is reduced by a one-term truncation to a system of nonlinear ordinary differential equations representing the complete dynamics of the electromechanical system. First, the steady-state behavior is analyzed. It turns out that a constant crank rotational speed is not possible: fluctuations appear which can be limited by an appropriate choice of the system and the engine data. Then, the transient startup or rundown is dealt with by using a digital simulation of the model equations. It exhibits a rich variety of dynamic effects till the stationary speed is reached. Attention is focused on the influence of the flexibility which in both categories of motion yields typical features.     

Supersonic Inviscid Corner Flows with Regular and Irregular Shock Interaction

The results of a numerical and analytical investigation of steady-state supersonic inviscid flows in corners formed by intersecting compression wedges are presented. The flows considered are symmetric about the corner bisector. The distinctive features of flow pattern formation related with the reflection of wedge-generated shocks from the bisector plane are studied. The wedge angles at which transition from regular to irregular shock reflection occurs are determined both numerically and analytically using the criteria available for plane flows; the data thus obtained are found to be in agreement. Flow patterns with irregular shock reflection, namely, single, transitional, and double Mach, as well as von Neumann reflection, are identified; they are similar to the known types of reflection for plane quasi-steady-state flows. Varieties of these types not observed in the plane flows are found to exist. The effects of the angle of inclination of the plane surfaces of the corner to the freestream direction, the sweep angle of the leading edges, and the dihedral angle are investigated. Some previously unknown parameters of corner configurations for which transition may occur in accordance with the von Neumann criterion are determined.     

Traveling Waves of a Singularly Perturbed System of Integral–Differential Equations Arising from Neuronal Networks

A nonlinear nonlocal model arising from synaptically coupled neuronal networks with two integral terms is considered. The existence and stability of several traveling wave solutions are established by using ideas in differential equations and functional analysis. Steady-state solutions of some inhomogeneous integral–differential equations are also investigated. We consider several types of kernel functions: (I) positive functions, such as and , where ρ>0 is a constant; (II) nonnegative kernels with compact supports, for examples, (i) 1$$" align="middle" border="0"> , and (ii) {\pi\over 2}$$" align="middle" border="0"> ; (III) Mexican hat type kernel functions, such as and , where A>B>0 and a>b>0 are constants.Dedicated to Professor Yulin Zhou and Professor Boling Guo on the Occassions of their birthdays.     

Instability of the Motion of a Drop in Filtration Flows

The behavior of an inclusion (drop) of foreign fluid in a porous medium saturated with another fluid is considered. A steady-state regime of gravity-induced drop settlement is found and the instability of this regime is demonstrated. The horizontal motion of a liquid inclusion under the action of a stationary reservoir pressure gradient is also studied.     

复杂边界条件下渗流场流线分布研究

流线分布研究已受到油藏工程师们的普遍关注。本文从无限大油藏稳态渗流场基本解出发,结合边界元方法求解出复杂边界条件下稳态渗流场的势分布,以此为基础提出了流线场的生成办法,并给出了应用实例。本文方法的优点在于求解过程中将问题的维数降低了一维,减少了计算量;计算精度较高且具有一定的普遍应用性;适应于求解任意形状的包括定压、定流量或混合边界在内的组合边界问题。实例表明,利用本文方法产生的流线分布因能够较为直观地反映出油藏流体在注采井间的运动轨迹,为优化井网和注入方案提供了重要依据。     

变速转子准稳态主动平衡系统的增益调度控制

在现代高速旋转机械中,不平衡引起的振动是机器性能降低甚至损坏的重要原因。对变速转子准稳态主动平衡系统,可按一定时间步长把变转速离散成有限个转动角速度。针对每个离散角速度,依据影响系数法,采用包含残余振动值和校正不平衡的广义线性二次型目标性能函数推导出控制律。通过每个离散转速下影响系数的估计和增益矩阵的计算,形成对应于各离散转速的增益表,从而实现变速转子准稳态主动平衡系统的增益调度控制。数值模拟验证了增益调度控制能很好地抑制不平衡振动。与传统的加权二乘法(WLS)相比,数值模拟显示,该法对校正不平衡的惩罚可提高系统的稳定性,也可增强控制的鲁棒性。